Extracting protein alignment models from the sequence database
نویسندگان
چکیده
منابع مشابه
Extracting protein alignment models from the sequence database.
Biologists often gain structural and functional insights into a protein sequence by constructing a multiple alignment model of the family. Here a program called Probe fully automates this process of model construction starting from a single sequence. Central to this program is a powerful new method to locate and align only those, often subtly, conserved patterns essential to the family as a who...
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In the context of protein structure prediction, there are two principle reasons for comparing and aligning protein sequences: (a) To obtain an accurate alignment. This may be for protein modelling by comparison to proteins of known three-dimensional structure. (b) To scan a database with a newly determined protein sequence and identify possible functions for the protein by analogy with well-cha...
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Protein sequence alignment is the task of identifying evolutionarily or structurally related positions in a collection of amino acid sequences. Although the protein alignment problem has been studied for several decades, many recent studies have demonstrated considerable progress in improving the accuracy or scalability of multiple and pairwise alignment tools, or in expanding the scope of task...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1997
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/25.9.1665